CYP3A5*3,CYP3A4*1BandMDR1C3435T Genotype Distributions in Ecuadorians

[摘要] Polymorphisms inCYP3Agenes, such asCYP3A5andCYP3A4, as well as in theMDR1gene, which encodes for P-glycoprotein, have been implicated as genetic markers in several disorders. Differences in the frequency distribution of the allelic variantsCYP3A5*3,CYP3A4*1B, andMDR13435T have been demonstrated between distinct ethnic groups. In this study we examined the frequency of these allelic variants in 317 healthy Mestizo individuals from Ecuador and made comparisons with results reported in the literature. The genotypes were determined by PCR-RFLP. Allele and genotype differences were studied by chi-square test. TheMDR1T allele frequency was similar to that of Spaniard or Asian populations, which is consistent with the ethnic origin of Ecuadorian Mestizo individuals (Amerindian and Spaniard Caucasians). By contrast, theCYP3A5*3allele frequency was significantly lower in Ecuadorians than in Spaniards and other white populations and higher than in Central Americans, Asians and blacks.CYP3A4*1Bwas more common in Ecuadorians than in Caucasian or Asian populations but less present than in blacks. The differences in the polymorphism found in this work should be considered in allele-disease association studies.

[学科分类] 生理学与病理学