Specific chromosomal IG translocations have different prognoses in chronic lymphocytic leukemia

[摘要] Chromosomal translocations are usually analyzed as a single entity, and are associated with a poor outcome in chronic lymphocytic leukemia. Translocations involving immunoglobulin genes are recurrent, but uncommon (<5%), and their individual prognosis is not clear. The two most frequent partners are BCL2 (18q21) and BCL3 (19q13).

[学科分类] 血液学

[关键词] Chronic lymphocytic leukemia;IGH;BCL2;chromosomal translocation