The Association between Myocardial Iron Load and Ventricular Repolarization Parameters in Asymptomatic Beta-Thalassemia Patients

[摘要] Previous studies have demonstrated impaired ventricular repolarization in patients withβ-TM. However, the effect of iron overload with cardiacT2*magnetic resonance imaging (MRI) on cardiac repolarization remains unclear yet. We aimed to examine relationship between repolarization parameters and iron loading using cardiacT2*MRI in asymptomaticβ-TM patients. Twenty-twoβ-TM patients and 22 age- and gender-matched healthy controls were enrolled to the study. From the 12-lead surface electrocardiography, regional and transmyocardial repolarization parameters were evaluated manually by two experienced cardiologists. All patients were also undergone MRI for cardiacT2*evaluation. CardiacT2*score <20 msec was considered as iron overload status. Of the QT parameters, QT duration, corrected QT interval, and QT peak duration were significantly longer in theβ-TM group compared to the healthy controls.Tp−TeandTp−Tedispersions were also significantly prolonged inβ-TM group compared to healthy controls.(Tp-Te)/QTwas similar between groups. There was no correlation between repolarization parameters and cardiacT2*MRI values. In conclusion, although repolarization parameters were prolonged in asymptomaticβ-TM patients compared with control, we could not find any relation between ECG findings and cardiac iron load.

[学科分类] 血液学