Liposome-Based Delivery Systems in Plant Polysaccharides

[摘要] Plant polysaccharides consist of many monosaccharide byα- orβ-glycosidic bond which can be extracted by the water, alcohol, lipophile liquid from a variety of plants includingCordyceps sinensis, astragalus, and mushrooms. Recently, many evidences illustrate that natural plant polysaccharides possess various biological activities including strengthening immunity, lowering blood sugar, regulating lipid metabolism, antioxidation, antiaging, and antitumour. Plant polysaccharides have been widely used in the medical field due to their special features and low toxicity. As an important drug delivery system, liposomes can not only encapsulate small-molecule compound but also big-molecule drug; therefore, they present great promise for the application of plant polysaccharides with unique physical and chemical properties and make remarkable successes. This paper summarized the current progress in plant polysaccharides liposomes, gave an overview on their experiment design method, preparation, and formulation, characterization and quality control, as well asin vivoandin vitrostudies. Moreover, the potential application of plant polysaccharides liposomes was prospected as well.

[学科分类] 材料工程