Magnetic Nanoparticle Hyperthermia Using Pluronic-CoatedFe3O4Nanoparticles: AnIn VitroStudy

[摘要] Magnetic nanoparticles are promising materials for hyperthermia treatment. The temperature rise under ac magnetic field, cytotoxicity, andin vitrohyperthermia effect ofFe3O4nanoparticles coated with Pluronic f-127 were evaluated in this paper. The Pluronic-coatedFe3O4nanoparticles exhibited no cytotoxic effect on HeLa cells. The optimal magnetic field of Pluronic-coatedFe3O4nanoparticles was 16 kA/m (200 Oe) at the field strength of 210 kHz. Appropriate temperature rise significantly reduced the viability of HeLa cells and induced apoptosis.

[学科分类] 材料工程