Determination of the enantiomeric composition of chiral delta-2-thiazolines-1,3 by1H and19F NMR spectroscopy using chiral solvating agents

[摘要] Studies of the perturbing effect of chiral solvating agents (CSAs) namely the fluoroalcohols5aand5bupon the NMR spectra of chiral Δ2-thiazolines1presenting interesting insecticidal properties demonstrated the ability of these CSAs to afford diastereomeric solvates from these substrates providing their enantiomeric discrimination. Thus, for five of the six tested Δ2-thiazolines1Aand1Bthere is at least one possibility to proceed to their enantiomeric discrimination either by1H or19F NMR using mostly5bas CSA.

[学科分类] 光谱学