Female Sprague Dawley Rats Show Impaired Spatial Memoryin the 8-Arm Radial Maze under Dim Blue and Red Light

[摘要] Light intensity and wavelength strongly influence mood and cognition in humans and rodent animal models. The aim of the present study was to explore if dim white (7.6–17.7 lux) , blue (1.3–2.3 lux), and red light (0.8–1.4 lux) affect spatial memory of male and female Sprague Dawley rats in the 8-arm radial maze. Our data show that spatial memory significantly improved within 5 daily learning sessions (each 5 trials) under dim white light, which was not different between male and female rats. However, dim blue and red light significantly reduced spatial learning of female rats in the 8-arm radial maze in the last training session (session 5). In conclusion, we suggest that female Sprague Dawley rats show reduced learning under blue and red light.

[学科分类] 动物科学