Fulminant Type 1 Diabetes as a Model of Nature to Explore the Role of C-Peptide

[摘要] Patients with fulminant type 1 diabetes almost completely lackC-peptide even soon after the onset of the disease, and the deficiencycontinues for the rest of their life. Thus, fulminant type 1 diabetescould serve as a good model of nature to explore the physiological roleof C-peptide. For example, patients with fulminant type 1 diabetes havediabetic chronic complications more frequently than those with classicalautoimmune type 1 diabetes 5 years after the onset of diabetes, and thehigher prevalence could be partly attributable to the complete lack ofC-peptide in fulminant type 1 diabetes.

[学科分类] 内分泌与代谢学