The Effect of Sub-MICβ-Lactam Antibiotic Exposure ofPseudomonas aeruginosaStrains from People with Cystic Fibrosis in a Desiccation Survival Model

[摘要] Prior to modern typing methods, cross-infection ofP. aeruginosabetween people with cystic fibrosis (CF) was felt to be rare. Recently a number of studies have demonstrated the presence of clonal strains ofP. aeruginosainfecting people with CF. The aim of this study was to determine whether strains ofP. aeruginosademonstrated differences in resistance to desiccation and whether preincubation in subminimum inhibitory concentrations (MICs) ofβ-lactam affected desiccation resistance. The experimental data were modelled to a first-order decay model and a Weibull decay model using least squares nonlinear regression. The Weibull model was the preferred model for the desiccation survival. The presence of a mucoid phenotype promoted desiccation survival. Preincubation with antibiotics did not have a consistent effect on the strains ofP. aeruginosa. Meropenem reduced desiccation resistance, whereas ceftazidime had much less effect on the strains studied.

[学科分类] 微生物学和免疫学