The Lantibiotic Lacticin 3147 Prevents Systemic Spread ofStaphylococcus aureusin a Murine Infection Model

[摘要] The objective of this study was to investigate thein vivoactivity of the lantibiotic lacticin 3147 against the luminescentStaphylococcus aureusstrain Xen 29 using a murine model. Female BALB/c mice (7 weeks old, 17 g) were divided into groups (n=5) and infected with the Xen 29 strain via the intraperitoneal route at a dose of1×106 cfu/animal.After 1.5 hr, the animals were treated subcutaneously with doses of phosphate-buffered saline (PBS; negative control) or lacticin 3147. Luminescent imaging was carried 3 and 5 hours postinfection. Mice were then sacrificed, and the levels ofS. aureusXen 29 in the liver, spleen, and kidneys were quantified. Notably, photoluminescence and culture-based analysis both revealed that lacticin 3147 successfully controlled the systemic spread ofS. aureusin mice thus indicating that lacticin 3147 has potential as a chemotherapeutic agent forin vivoapplications.

[学科分类] 微生物学和免疫学