Younger Age Is an Independent Predictor for Poor Survival in Patients with Signet Ring Prostate Carcinoma

[摘要] Objective.The aim of this study was to examine the epidemiology, natural history, treatment pattern, and predictors of long-term survival of signet ring prostate carcinoma (SRPC) patients based on the analysis of the national Surveillance, Epidemiology, and End Results (SEER) database.Methods & Results. Between 1980 and 2004, a total of 93 patients with pathologically confirmed SRPC were identified.The mean age was70±11years old. 82.8% of the patients had poorly or undifferentiated histology grade. 13.9% patients presented with metastatic disease. The 1-, 3-, and 5-year cancer-specific survival rates were 94.6%, 89.6%, and 83.8%, respectively.Using multivariate Cox proportional hazard model, younger age (40–50 versus age >70 yrs,P=.01), advanced tumor stage (distant versus local/regional,P=.02), and earlier diagnosis year (before 1995 versus after 1995,P=.01) were predictors of worse cancer specific survival.Conclusions.Despite more aggressive cancer therapy, younger SRPC patients had a worse cancer specific survival.This information could be useful when counseling these patients and emphasizes the need fornew strategies and molecular-based therapeutic approaches for younger patients with SRPC.

[学科分类] 肿瘤学