Blood Level Omega-3 Fatty Acids as Risk Determinant Molecular Biomarker for Prostate Cancer

[摘要] Previous researches involving dietary methods have shownconflicting findings. Authors sought to assess the association ofprostate cancer risk with blood levels of omega-3 polyunsaturatedfatty acids (n-3 PUFA) through a meta-analysis of humanepidemiological studies in available online databases (July,2012). After critical appraisal by two independent reviewers,Newcastle-Ottawa Quality Assessment Scale (NOQAS) was used tograde the studies. Six case control and six nested case controlstudies were included. Results showed nonsignificant associationof overall effect estimates with total or advanced prostate canceror high-grade tumor. High blood level of alpha-linolenic acid(ALA) had nonsignificant positive association with total prostatecancer risk. High blood level of docosapentaenoic acid (DPA) hadsignificant negative association with total prostate cancer risk. Specific n-3 PUFA in fish oil, eicosapentaenoic acid (EPA), anddocosahexaenoic acid (DHA) had positive association withhigh-grade prostate tumor risk only after adjustment of interstudyvariability. There is evidence that high blood level of DPA thatis linked with reduced total prostate cancer risk and elevatedblood levels of fish oils, EPA, and DHA is associated withhigh-grade prostate tumor, but careful interpretation is neededdue to intricate details involved in prostate carcinogenesis andN-3 PUFA metabolism.

[学科分类] 肿瘤学