An Innovative Mathematical Model: A Key to the Riddle ofHbA1c

[摘要] HbA1cis a standard clinical assessment of glycemia and the basis of most data relating glycemic control to complications. While daily blood glucose testing gives a picture of day-to-day fluctuations, theHbA1ctest offers an overview of how well glucose has been controlled over the past 4 months. I devised an innovative mathematical model to describe novel equations governingHbA1cwhich enables analysis ofHbA1cbehavior and provides emerging new concepts in assessment of diabetes management. Linear relationship ofHbA1cand mean plasma glucose along with the kinetic analysis ofHbA1cformation has been used as the basic suppositions to construct this model. The main application of this devised model is prediction of mean plasma glucose at any desired point in time after a change in therapy and with great certainty. This model also appraises the pattern ofHbA1cchanges over time and provides a unique opportunity to address common mistakes and misconceptions in routine application ofHbA1cthat could have potentially important implications on diabetes control.

[学科分类] 内分泌与代谢学