Vitamin D Levels and Lipid Response to Atorvastatin

[摘要] Adequate vitamin D levels are necessary for good vascular health. 1,25-dihydroxycholecalciferol activates CYP3A4, an enzyme of the cytochrome P450 system, which metabolizes atorvastatin to its main metabolites. The objective of this study was to evaluate the response of cholesterol and triglycerides toatorvastatin according to vitamin D levels. Sixty-three patients with acute myocardial infarction treated with low and high doses of atorvastatin wereincluded. Levels of total cholesterol, triglycerides, HDL cholesterol, and LDL cholesterolwere measured at baseline and at 12 months of follow-up. Baselinelevels of 25-hydroxyvitamin D (25-OHD) were classified as deficient (<30 nmol/L), insufficient (30–50 nmol/L), and normal (>50 nmol/L). In patients with25-OHD<30 nmol/L, there were no significant changes in levels of totalcholesterol (173±47 mg/dL versus164±51 mg/dL), triglycerides (151±49 mg/dLversus177±94 mg/dL), and LDL cholesterol (111±48 mg/dL versus 9245± mg/dL); whereas patients with insufficient (30–50 nmol/L) and normal vitamin D (>50 nmol/L) had a good response to atorvastatin. We suggest that vitamin Dconcentrations>30 nmol/L may be required for atorvastatin to reduce lipidlevels in patients with acute myocardial infarction.

[学科分类] 内分泌与代谢学