Facile Synthesis, Characterization, andIn VitroAntimicrobial Screening of a New Series of 2,4,6-Trisubstituted-s-triazine Based Compounds

[摘要] A series of new 2,4,6-trisubstituted-s-triazine was synthesized, assessed for antimicrobial activity, and characterized by FTIR,1HNMR,13CNMR, and elemental analysis. The tested compounds,4d,4g,4h,4k, and4n, have shown considerablein vitroantibacterial efficacy with reference to the standard drug ciprofloxacin (MIC 3.125 μgmL−1againstB. subtilis,E. coli, andK. pneumoniae). It was observed that compounds4dand4hdisplayed equipotent antibacterial efficacy againstB. subtilis(MIC 3.125 μgmL−1) andS. aureus(MIC 6.25 μgmL−1). The studies demonstrated that thepara-fluorophenylpiperazine substituteds-triazine (4n) was potent and exhibited broad spectrum antibacterial activity againstS. epidermidis,K. pneumoniae, andP. aeruginosawith MIC of 6.25 μgmL−1and forE. coli, it showed an MIC of 3.125 μgmL−1equipotent with reference to the standard drug. Among all the compounds under investigation, compound4galso demonstrated significant antifungal activity (3.125 μgmL−1) againstC. albicans.

[学科分类] 药学