A report of the first international WT1 meeting, University of Manchester UK, 2008

[摘要] On September 8th-9th 2008, scientists from Europe, North America and Japan gathered together at the University of Manchester (UK) at a meeting about all things WT1. The intent was to bring together recent advances in research focused on the Wilms' tumor suppressor gene WT1 from different subject areas. The WT1 gene has emerged as a key player in development and cancer in recent years. The subject areas ranged from developmental mouse genetics including kidney development, cancer cell biology, structural analysis and molecular processes and targets regulated by WT1. The meeting was jointly organized by Dr Stefan Roberts (University of Manchester, UK); Dr Michael Ladomery (University of the West of England, UK); and Prof. Nick Hastie (MRC Human Genetics Unit, UK). In this article we review the contents of the meeting, subdividing it into three broad and overlapping subject areas: new findings in the context of A) WT1's role in development; B) WT1's involvement in cancer; and C) the biochemistry of WT1 protein.

[学科分类] 流行病学

[关键词] WT1;Wilms' tumor;oncogene;tumor suppressor;cancer;development