Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine

[摘要] Novel ruthenium(III) complexes with histamine[RuCl4(dmso-S)(histamineH)]·H2O(1a) and[RuCl4(dmso-S)(histamineH)](1b) have been prepared and characterized by X-ray structure analysis. Their crystal structures are similar and show a protonated amino group on the side chain of the ligand which is not very common for a simple heterocyclic derivative such as histamine. Biological assays to test the cytotoxicity of the compound1bcombined with electroporation were performed to determine its potential for future medical applications in cancer treatment.

[学科分类] 物理化学和理论化学