Organotin Compound Derived from 3-Hydroxy-2-formylpyridineSemicarbazone: Synthesis, Crystal Structure, andAntiproliferative Activity

[摘要] The novel diphenyltin(IV) compound[Ph2(HyFoSc)Sn](2), whereH2HyFoSc(1) is 3-hydroxy-2-formylpyridine semicarbazone, was prepared and characterized by vibrationaland NMR (1H,13C) spectroscopy. The structure of [Ph2(HyFoSc)Sn] was confirmed by single-crystal X-ray crystallography. The doubly deprotonated ligand is coordinated to the tin atom through the enolic-oxygen, the azomethine-nitrogen, and phenolic-oxygen, and so acts as an anionic tridentate ligand with the ONO donors.Two carbon atoms complete the fivefold coordination at the tin(IV) center. Intermolecular hydrogen bonding,C–H→π, andπ→πinteractions combine to stabilize the crystal structure. Compounds1and2have been evaluated for antiproliferative activity in vitro against the cells of three human tumor cell lines: MCF-7 (human breast cancer cell line), T24 (bladder cancer cell line), A549 (nonsmall cell lung carcinoma), and a mouse fibroblast L-929 cancer cell line.

[学科分类] 物理化学和理论化学