Clinical Profile ofPlasmodium vivaxMalaria in Children and Study of Severity Parameters in relation to Mortality: A Tertiary Care Centre Perspective in Mumbai, India

[摘要] Background. While research onP. vivaxis scarce because it is considered benign, it has become evident with implementation of molecular diagnosis that it can also cause multiple organ dysfunction and severe life-threatening disease.Objective. To study clinical presentations and complications ofP. vivaxmalaria and mortality correlation to severity parameters as defined by WHO criteria for severe malaria.Materials and methods. This study was conducted in a tertiary care centre in Mumbai. ConfirmedP. vivaxcases were enrolled and studied for their clinical profile, and WHO severity parameters were tested for their frequency and association to mortality.Result. The most common presentation was fever followed by pallor. 26% of the cases satisfied one or more criteria of WHO severity parameters. 2 cases died; both had pulmonary edema and bleeding. The major predictor of mortality among these predefined severity criteria was pulmonary edema/ARDS. Patients with severe anemia, circulatory collapse, and repeated generalized convulsion had 100% survival rate. Leukopenia was present in 10% of the cases. Both cases with mortality had leukopenia.Conclusion.P. vivaxmonoinfection tends to have severe complications in children. There is a need to review severity criteria forP. vivaxmalaria.

[学科分类] 传染病学