Antimalarial Effects of Iranian FloraArtemisia sieberionPlasmodium berghei In Vivoin Mice and Phytochemistry Analysis of Its Herbal Extracts

[摘要] The aim of this study is pharmacochemistry of Iranian floraArtemisia sieberiand its antimalarial effects onPlasmodium berghei in vivo. This is the first application ofA. sieberifor treatment of murine malaria.A. sieberiwere collected at flowering stage from the Khorassan and Semnan provinces of Iran; the aerial parts were air-dried at room temperature and then powdered. Thepowder was macerated in methanol, filtered with Bokhner hopper and solvent was separated in rotary evaporator. Total herbal extract was subsequently processed for ether and chloroform extracts preparation. The toxicity of herbal extract was assessed on naive NMRI mice with high, average and low doses; then pathophysiological signs were assessed. Finally, the antimalarial efficacy was investigated on two groups ofPlasmodium bergheiinfected mice. Percentage of parasitaemia and pathophysiology were also evaluated. The results of this assessment showed no toxicity even by high concentration of herbal extract. A significant reduction in percentage of parasitaemia was observed; no alterations of hepatosplenomegaly and body weight were indicated in study group.A. sieberiextracts showed antimalarial effects against murine malaria with some efficacies on reducing pathophysiology. However, there is requirement to find the major component of this herbal extract by further studies.

[学科分类] 传染病学