In VitroChloroquine Resistance inPlasmodium falciparumIsolates from Tertiary Care Hospital

[摘要] Chloroquine (CQ) has been the mainstay of treatment of malaria for decades. This cost-effective and safe drug has become ineffective for treatment offalciparummalaria in many parts of the world due to development of resistance by the parasite. In addition CQ is not gametocytocidal forP. falciparumand thus cannot block transmission. The extent of problem of chloroquine resistance inP. falciparumis increasing every year. The study was done in period of 2 years. A total of 5653 specimens were examined for malarial infection by employing different diagnostic modalities. Four hundred and thirty-five were found to be positive forP. falciparumby using different diagnostic techniques. All positive specimens were cultured on RPMI 1640 medium; only 108 were found to be culture positive. Sensitivity of isolates to chloroquine was done using Mark III WHO sensitivity plates. The prevalence of malaria infection was found 9.54% in 2010. There were schizont formation at 8 pmol/liter or more of chloroquine concentration in 26 isolates. The emergence of chloroquine (CQ) resistance pattern in Aligarh isolates increases. Antimalarial agents should be used with caution; monotherapies should be avoided.

[学科分类] 传染病学