Correlation between PFGE Groups andmrp/epf/slyGenotypes of HumanStreptococcus suisSerotype 2 in Northern Thailand

[摘要] Streptococcus suisinfection is a severe zoonotic disease commonly found in Northern Thailand where people often consume raw pork and/or pig’s blood. The most frequent clinical presentations are meningitis, sepsis, and endocarditis with higher rate of mortality and hearing loss sequelae. To clarify the correlation between pulsed-field gel electrophoresis (PFGE) groups andmrp/epf/slygenotypes ofS. suisserotype 2, 62 patient and 4 healthy pig isolates from Northern Thailand were studied. By PFGE analysis, at 66% homology, most human isolates (69.4%) and 1 pig isolate were in group A, whereas 14.5% of human isolates and 3 out of 4 pig isolates were in group D. According tomrp/epf/slygenotypes, 80.6% of human isolates were identified inmrp+epf−sly−and only 12.9% were inmrp−epf−sly+genotypes; in contrast, 1 and 3 pig isolates were detected in these two genotypes, respectively. Interestingly, all isolates ofS. suisserotype 2 classified in PFGE groups A, B, and E were set inmrp+epf−sly−genotypes. These data show a close correlation between PFGE groups andmrp/epf/slygenotypes of humanS. suisserotype 2.

[学科分类] 医学微生物学