No Polymorphism inPlasmodium falciparum K13Propeller Gene in Clinical Isolates from Kolkata, India

[摘要] Molecular markers associated with artemisinin resistance inPlasmodium falciparumare yet to be well defined. Recent studies showed that polymorphisms inK13gene are associated with artemisinin resistance. The present study was designed to know the pattern of polymorphisms in propeller region ofK13gene among the clinical isolates collected from urban Kolkata after five years of ACT implementation. We collected 59 clinical isolates from urban Kolkata and sequenced propeller region ofK13gene in 51 isolates successfully. We did not find any mutation in any isolate. All patients responded to the ACT, a combination of artesunate + sulphadoxine-pyrimethamine. The drug regimen is still effective in the study area and there is no sign of emergence of resistance against artemisinin as evidenced by wild genotype ofK13gene in all isolates studied.

[学科分类] 医学微生物学