An Additive Effect of Oral N-Acetyl Cysteine on Eradication ofHelicobacter pylori

[摘要] Background. Helicobacter pyloriis highly adapted to the gastric environment where it lives within or beneath the gastric mucous layer. The aim of this study was to evaluate whether the addition of N-acetyl cysteine to the treatment regimen ofH. pyloriinfection would affect eradication rates of the disease.Methods.A total of 79H. pyloripositive patients were randomized to two therapeutic groups. Both groups received a 14-day course of three-drug regimen including amoxicillin/clarithromycin/omeprazole. Experimental group (38 subjects) received NAC, and control group (41 subjects) received placebo, besides three-drug regimen.H. pylorieradication was evaluated by urea breath test at least 4 weeks after the cessation of therapy.Results.The rate ofH. pylorieradication was 72.9% and 60.9% in experimental and control groups, respectively (P=0.005). By logistic regression modeling, female gender (OR 3.68, 95% CI: 1.06–5.79;P=0.040) and treatment including NAC (OR 1.88, 95% CI: 0.68–3.15;P=0.021) were independent factors associated withH. pylorieradication.Conclusion.The results of the present study show that NAC has an additive effect on the eradication rates ofH. pyloriobtained with three-drug regimen and appears to be a promising means of eradicatingH. pyloriinfection.

[学科分类] 医学微生物学