Is Subcellular Localization Informative for Modeling Protein-Protein Interaction Signal?

[摘要] Statistical methods have been intensively applied in genomic signal processing(Dougherty et al. 2005). For budding yeastSaccharomycescerevisiaewith around 6000 proteins, genome-wideprotein-protein-interaction (PPI) (Fromont-Racine et al. 2000, Itoet al. 2001, Newman et al. 2000, and Uetz et al. 2000 amongothers) and protein subcellular localization (PSL) (Huh et al.2003) data recently became available and for the latter thepresence of 4152 proteins is experimentally tested in each of the22 subcellular compartments. Recent work shows that multiplebiological sources are helpful for both PSL and PPI predictions,and this paper studies statistical feasibility of modeling PPIfrom PSL since PSLs may play different marginal or joint roles inthe complex regulatory network. However, our results indicate thatPSL may be controversial for this purpose as an independentsource.

[学科分类] 电子、光学、磁材料