Second Surgery in Insular Low-Grade Gliomas

[摘要] Background. Given the technical difficulties, a limited number of works have been published on insular gliomas surgery and risk factors for tumor recurrence (TR) are poorly documented.Objective. The aim of the study was to determine TR in adult patients with initial diagnosis of insular Low-Grade Gliomas (LGGs) that subsequently underwent second surgery.Methods. A consecutive series of 53 patients with insular LGGs was retrospectively reviewed; 23 patients had two operations for TR.Results. At the time of second surgery, almost half of the patients had experienced progression into high-grade gliomas (HGGs). Univariate analysis showed that TR is influenced by the following: extent of resection (EOR) (P<0.002), ΔVT2T1value (P<0.001), histological diagnosis of oligodendroglioma (P=0.017), and mutation of IDH1 (P=0.022). The multivariate analysis showed that EOR at first surgery was the independent predictor for TR (P<0.001).Conclusions. In patients with insular LGG the EOR at first surgery represents the major predictive factor for TR. At time of TR, more than 50% of cases had progressed in HGG, raising the question of the oncological management after the first surgery.

[学科分类] 基础医学