Radiation-Induced Leiomyosarcoma: Does Antimetabolite ChemotherapyContribute? A Report of Three Cases

[摘要] Purpose:Radiation therapy in low and high doses is known to be associated with the occurrence of late secondary sarcomas.The addition of chemotherapy has not been clearly demonstrated as a contributing factor. We describe three patients withradiation-associated leiomyosarcoma who had also received antimetabolite chemotherapy.Methods:Three cases of leiomyosarcoma occurring 9–27 years after radiation and antimetabolite chemotherapy arepresented, along with histopathological details. A Medline search was used to assess prior reports of leiomyosarcoma afterradiation.Results:These three cases appear to be the first reported in which leiomyosarcoma followed therapy with radiation andantimetabolites.Discussion:With the increasing use of antimetabolite therapy combined with radiation, there is the potential for moreoccurrences of leiomyosarcoma or other post-treatment sarcomas.

[学科分类] 肿瘤学