Comments on Cultured Human Sarcoma Cells

[摘要] Human sarcoma cell populations maintained in culture reflect to the native tumor cells better if the culture retains thosenonmalignant cells that comprised the tumor's microenvironmentin vivo[Hu M,et al. Characterization of 11 humansarcoma cell strains.Cancer2002; 95: 1569–76] and thus provide paracrine growth factors and protection from apoptoticdeath to the tumor cells. Whereas sarcoma cell cultures obtained through meticulous efforts aimed at the elimination of allnon-malignant cells of the tumor's original microenvironment consist of subpopulations of tumor cells growing exclusivelywith the support of their own autocrine growth loops [Sinkovics JG,et al. Growth of human tumor cells in establishedcultures. In: Busch H, ed.Methods in Cancer Research. Vol 14. New York: Academic Press, 1978; 243–323].

[学科分类] 肿瘤学