Soft Tissue Sarcoma of the Hand or Foot: Conservative Surgery andRadiotherapy

[摘要] Purpose.Conservative treatment in the form of limited surgery and post-operativeradiotherapy is controversial in hand and foot sarcomas, both due to poor radiationtolerance of the palm and sole, and due to technical difficulties in achieving adequatemargins.This paper describes the local control and survival of 41 patients with soft tissuesarcoma of the hand or foot treated with conservative surgery and radiotherapy.The acute and late toxicity of megavoltage radiotherapy to the hand and foot are described.The technical issues and details of treatment delivery are discussed.The factors influencing local control after radiotherapy are analysed.Subjects .Eighteen patients had sarcomas of the hand and 23 of the foot.All patients received post-operative radiotherapy, the majority receiving a dose of 60Gy in 2-Gy daily fractions using a two-phase treatment.Results .The acute and late toxicity of treatment were within acceptable limits.The actuarial 5-year overall survival of the whole patient group was 67.6% and thelocal relapse-free survival was 44%.The local control was similar in tumours of handand foot, and in patients treated at first presentation or relapse.Discussion.Post-operative radiotherapy to the hand or foot appears to be a welltolerated treatment resulting in long-term local control in a significant proportion of patients.The increased frequency of recurrence within the high-dose volume suggests the need for the use of higher total doses of radiotherapy.

[学科分类] 肿瘤学