Soft Tissue Tumours of the Retroperitoneum

[摘要] Purpose.This review summarizes the more prevalent soft tissuetumours arising in the retroperitoneum and highlights some recent fundamental anddiagnostic developments relevant to mesenchymal tumours.Discussion.The retroperitoneum is an underestimated site for benignand malignant neoplastic disease, and represents the second most common site of originof primary malignant soft tissue tumours (sarcomas) after the deep tissues of the lower extremity. In contrast to the predominance of benign soft tissue lesions over malignant sarcomas elsewhere, retroperitoneal mesenchymal lesions are far more likely to be malignant. The differential diagnosis is primarily with the more common lymphoproliferative and parenchymatous epithelial lesions arising in this area, and with metastatic disease from known or unknown primary sites elsewhere.The most prevalent mesenchymal tumours at this site are of a lipomatous, myogenic or neural nature.Their generally late clinical presentation and poorly accessible location provides numerous clinical challenges; optimal radiological imaging and a properly performed biopsy are essential cogs in the management route. Histopathological diagnosis may be complicated, but has been aided by developments in the fields of immunohistochemistry and tumour (cyto)genetics. Despite significant advances in oncological management protocols, the prognosis remains generally less favourable than for similar tumours at more accessible sites.

[学科分类] 肿瘤学