Gemcitabine in Bone Sarcoma Resistant to Doxorubicin-BasedChemotherapy
[摘要] Subjects and Methods:Seven patients with progressive localized ormetastatic chemo-resistant osteosarcoma were treated by gemcitabine.The protocolincluded gemcitabine 1000 mg/m2/w for 7 consecutive weeks, followed by 1 week rest. If no progression was observed,maintenance by gemcitabine 1000 mg/m2/w for 3 weeks every 28 days was given until failure was clinically or radiologically evident.Results.The true objective response rate was 0%. However, disease stabilization and clinical benefit response were observed in five patients (70%) for 13–96 weeks.Discussion.Postponing the inevitable death with a relatively non-toxic treatment, is, in our opinion, an important issue especially in young patients.Thus it may be justified and warranted to investigate the activity of gemcitabine in a larger groupof patients with bone sarcomas.
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[效力级别] [学科分类] 肿瘤学
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