The Treatment and Outcome of Patients With Soft Tissue Sarcomas and Synchronous Metastases

[摘要] Introduction:There is a strong association between poor overall survival and a short disease-free interval for patients withsoft tissue sarcomas (STS) and metastatic disease. Patients with STS and synchronous metastases should have a very dismalprognosis.The role of surgery in this subgroup of patients with STS has not been defined.Patients and Methods:A single-institution retrospective review was performed of 48 patients with STS and synchronousmetastases in regard to patient demographics, presentation, tumor characteristics, metastatic sites, treatment, follow-up, andsurvival over a 27-year period.Results:Most primary tumors were≥10cm (58%), high-grade histology (77%), and located on the extremity (60%).Themost frequent site of metastatic disease was the lung (63%); 27% of patients had metastases to≥2organ sites. Surgery tothe primary tumor was performed in 94% of patients (n= 45) and 68% had additional radiation therapy (n= 32). Thirty-five percent of patients underwent at least one metastastectomy (n= 17). Chemotherapy was administered to 90% of patients(n= 43); 31% received≥3different regimens (n= 15) and 25% were given intra-arterial or intracavitary therapy (n= 12).Median overall survival was 15 months with a 21% 2-year survival. Local control of the primary tumor was achieved in 54%(n= 26), and metastastectomy was performed in 35% (n= 17). No analyzed factors were associated with an improvementin overall survivalConclusions:Despite multiple poor prognostic factors, the survival of patients with STS and metastases is comparable tothose who develop delayed metastatic disease. However, unlike patients who present with metachronous disease, there wasno improved survival observed for patients treated with metastastectomy. Consequently, treatment for patients with STSand synchronous metastases should be approached with caution. Surgical management of STS with synchronous metastasesmust be considered palliative and should be reserved for patients requiring palliation of symptoms. Patients must alsobe well informed of the noncurative nature of the procedure.

[学科分类] 肿瘤学