Proteomics in Vaccinology and Immunobiology:An Informatics Perspective of the Immunone

[摘要] The postgenomic era, as manifest, inter alia, by proteomics,offers unparalleled opportunities for the efficient discovery ofsafe, efficacious, and novel subunit vaccines targeting a trancheof modern major diseases. A negative corollary of this opportunityis the risk of becoming overwhelmed by this embarrassment ofriches. Informatics techniques, working to address issues of bothdata management and through prediction to shortcut theexperimental process, can be of enormous benefit in leveragingthe proteomic revolution.In this disquisition, we evaluateproteomic approaches to the discovery of subunit vaccines,focussing on viral, bacterial, fungal, and parasite systems. Wealso adumbrate the impact that proteomic analysis ofhost-pathogen interactions can have. Finally, we review relevantmethods to the prediction of immunome, with special emphasis onquantitative methods, and the subcellular localization ofproteins within bacteria.

[学科分类] 基础医学