Biomolecular Interaction Study of Cyclolinopeptide A with Human Serum Albumin

[摘要] The kinetics, energetics, and structure of Cyclolinopeptide A binding with Human Serum Albumin were investigated with surface plasmon resonance and circular dichroism. The complex is formed through slow recognition kinetics that is temperature sensitive in the range of 20°C–37°C. The overall reaction was observed to be endothermic (ΔH=204 kJmol−1) and entropy driven (ΔS=746 Jmol−1K−1) with overall small changes to the tertiary structure.

[学科分类] 基础医学