High-Sensitivity C-Reactive Protein: An Independent Risk Factor for Left Ventricular Hypertrophy in Patients with Lupus Nephritis

[摘要] Objective. To determine the prevalence of left ventricular hypertrophy (LVH) and its associated risk factors in lupus nephritis (LN) patients.Methods. 287 LN patients (age: 38.54±13.31, 262 female) were recruited. Echocardiography and serum high-sensitivity C-reactive protein (hs-CRP) were measured. Their relationship was evaluated by univariate correlation analysis and multivariate regression analysis.Results. The prevalence of LVH in this cohort was 21.25% (n=61). Serum hs-CRP level was significantly elevated in patients with LVH compared to those without (8.03 (3.22–30.95) versus 3.93 (1.48–9.48) mg/L,P<.01), and correlated with left ventricular mass index (LVMI) (r=0.314,P=.001). Multivariate regression analysis further confirmed that hs-CRP was an independent risk factor (β=0.338,P=.002) for LVH in patients with LN.Conclusions. Our findings demonstrated that serum hs-CRP level is independently correlated with LVMI and suggested that measurement of hs-CRP may provideimportant clinical information to investigate LVH in LN patients.

[学科分类] 基础医学