Variability in Estrogen-Metabolizing Genes and Their Associationwith Genomic Instability in Untreated Breast Cancer Patients and Healthy Women

[摘要] In the present study, we investigated the relationship between polymorphisms in the estrogen-metabolizing genesCYP17, CYP1B1, CYP1A1,andCOMTand genomic instability in the peripheral blood lymphocytes of 62 BC patients and 62 controls considering that increased or prolonged exposure to estrogen can damage the DNA molecule and increase the genomic instability process in breast tissue. Our data demonstrated increased genomic instability in BC patients and that individuals with higher frequencies of MN exhibited higher risk to BC when belonging Val/Met genotype of theCOMTgene. We also observed thatCYP17andCYP1A1polymorphisms can modify the risk to BC depending on the menopause status. We can conclude that the genetic background in estrogen metabolism pathway can modulate chromosome damage in healthy controls and patients and thereby influence the risk to BC. These findings suggest the importance to ally biomarkers of susceptibility and effects to estimate risk groups.

[学科分类] 基础医学