Genome-Wide Transcriptional Profiling of the Response ofStaphylococcus aureusto Cryptotanshinone

[摘要] Staphylococcus aureus(S. aureus) strains with multiple antibiotic resistances are increasingly widespread, and new agents are required for the treatment ofS. aureus. Cryptotanshinone (CT), a major tanshinone of medicinal plantSalvia miltiorrhizaBunge, demonstrated effective in vitro antibacterial activity against all 21S. aureusstrains tested in this experiment. Affymetrix GeneChips were utilized to determine the global transcriptional response ofS. aureusATCC 25923 to treatment with subinhibitory concentrations of CT. Transcriptome profiling indicated that the antibacterial action of CT may be associated with its action as active oxygen radical generator;S. aureusundergoes an oxygen-limiting state upon exposure to CT.

[学科分类] 基础医学