Serodeconversion of HIV Antibody-Positive AIDS Patients Following Treatment with V-1 Immunitor

[摘要] It is extremely rare when HIV seropositive adult patients experience spontaneous lossof antibodies, that is, seroreversion. The disappearance of HIV antibodies was occasionallyattributed to iatrogenic intervention—serodeconversion. Such interventions include:HAART; oral interferon; Chinese herbal remedies; and therapeutic AIDS vaccinesderived from pooled blood. Oral therapeutic, alloimmune AIDS vaccine, V-1 Immunitor(V1), was administered to 60000 HIV-positive Thai patients. The administration of V1resulted in serodeconversion among 23 individuals. The patient group consisted of 9females (39%) and 14 males (61%) including two 2-year-old boys. The age range was2–58 years with mean/median 29/29.3 years. Patients were tested seropositive for HIVat least once before being enrolled on V1. The duration of treatment until discovery ofseronegative status ranged between 2 weeks and 15 months with average/median 7.2/8months. Time to seronegativity was correlated with baseline disease stage (R=0.62;P=.002). The seronegative status was positively associated with V1-inducedundetectable or low viral load (R=0.65;P=.0008). The odds ratio analysis comparingthe outcome of our study with published surveys of diagnostic accuracy of laboratorytests suggested that the probability of HIV antibody testing error was remote(P<.000001). The possible causes responsible for this unusual phenomenon arediscussed.

[学科分类] 基础医学