Role ofp53andCDKN2AInactivation in Human Squamous Cell Carcinomas

[摘要] p53tumor suppressor gene is the most commonly mutated gene in human and mouse cancers. Disruption of thep53andRbpathways is a fundamentaltrend of most human cancer cells. Inactivation ofCDKN2Acan lead to deregulation of these two pathways.Genetic abnormalities inCDKN2Agene have been well documented in human melanoma but their involvement in human nonmelanoma skin cancer (NMSC) and in particular in squamous cell carcinoma (SCC) is less clear.Several studies have shown that human SCCs harbour unique mutations in thep53gene as well as inactivation of theCDKN2Agene. While mutations in thep53gene are induced by UV radiation and represent tumor initiating events, the majority of alterations detected in theCDKN2Agene do not appear to be UV-dependent. In conclusion, in addition top53mutations, silencing of theCDKN2Agene might play a significant role in SCC development.

[学科分类] 基础医学