Preparation and Characterization of Poly(D,L-Lactide-co-Glycolide) NanoparticlesContaining Ascorbic Acid

[摘要] This paper is covering new, simplistic method of obtaining the system for controlled delivery of the ascorbicacid. Copolymer poly (D,L-lactide-co-glycolide) (DLPLG) nanoparticles are produced using physical methodwith solvent/nonsolvent systems where obtained solutions were centrifuged. The encapsulation of theascorbic acid in the polymer matrix is performed by homogenization of water and organic phases. Particles of the DLPLG with the different content of ascorbic acid have different morphological characteristics, that is, variable degree of uniformity, agglomeration, sizes, and spherical shaping. Mean sizes of nanoparticles, which contain DLPLG/ascorbic acid in the ratio85/150%, were between 130 to 200 nm depending on which stereologicalparameters are considered (maximal diameters Dmax, feret X, or feret Y). By introducingup to 15% of ascorbic acid, the spherical shape, size, and uniformity of DLPLG particlesare preserved. The samples were characterized by infrared spectroscopy, scanning electron microscopy, stereological analysis, and ultraviolet spectroscopy.

[学科分类] 基础医学