Expression of VE-Cadherin in Peritubular Endothelial Cells duringAcute Rejection after Human Renal Transplantation

[摘要] Genes involved in acute rejection (AR) after organ transplantation remain to be further elucidated. In a previous work we have demonstrated the under-expression of VE-Cadherin by endothelial cells (EC) in AR following murine and human heart transplantation. Serial sections from 15 human kidney Banff-graded transplant biopsieswere examined for the presence of VE-Cadherin and CD34 staining byimmunohistochemistry (no AR (n=5), AR grade IA (n=5), or AR grade IIA (n=5)). Quantification of peritubular EC staining were evaluated and results were expressed by the percentage of stained cells per surface analysed. There was no difference inCD34 staining between the 3 groups. VE-Cadherin expression was significantly reduced in ARGrade IIA when compared to no AR (P=.01) and to AR grade IA (P=.02). This study demonstrates a reduced VE-Cadherin expression by EC in AR after renal transplantation. The down-regulation of VE-Cadherin may strongly participate in human AR.

[学科分类] 基础医学