Werner Syndrome

[摘要] Werner syndrome is a premature aging disease caused by themutation in theWRNgene. The cloning andcharacterization of theWRNgene and its product allowsinvestigators to study the disease and the human aging process atmolecular level. This review summarizes the recent progresses onvarious aspects of theWRNresearch including functionalanalysis of the protein, interactive cloning, complexesformation, mouse models, and SNPs (single nucleotidepolymorphisms). These in depth investigations have greatlyadvanced our understanding of the disease and elucidated futureresearch direction for Werner syndrome and the human agingprocess.

[学科分类] 基础医学