Cytotoxic T lymphocyte-Associated Antigen +49G Variant Confers Risk for Anti-CCP- and Rheumatoid Factor-Positive Type of Rheumatoid Arthritis Only in Combination with CT60∗G Allele

[摘要] Controversial observations have been published on the association of the cytotoxic T lymphocyte associated antigen gene's variants with rheumatoid arthritis (RA). After genotyping 428 patients and 230 matched controls, the prevalence of theCT60∗G allele was more frequent in RF- and/or anti-CCP-seropositive RApatients, compared to the healthy controls (P<.001). Regression analysis revealed that theCT60∗G allele is a possible predisposing factor for RA in these subgroups. No accumulation of the+49∗G allele was found among patients, and this variant was not found to correlate with RA. Assaying the possible genotype variations, the+49∗G-CT60∗G allelic combination was accumulated in seropositive RA-subtypes, and was associated with the risk of RA (OR=1.73,P=.001for the whole RA-population). Although the+49∗G allele did not mean a predisposition to RA alone, in combination withCT60∗G it, also conferred risk, suggesting that the+49A/Gvariant is associated with the risk of RA only in certain haplotypes.

[学科分类] 内科医学