Long-Term Respiratory Muscle Endurance Training inPatients with Myasthenia Gravis: First Results after FourMonths of Training

[摘要] Myasthenia gravis (MG) is characterized by reduced muscle endurance and is often accompanied by respiratory complications. Improvement of respiratory function is therefore an important objective in MG therapy. A previous study demonstrated that respiratory muscle endurance training (RMET) over four weeks increased respiratory muscle endurance of MG patients to about 200% of baseline. The purpose of the present study was to establish an appropriate maintenance training and to test its effects over four months. Ten patients with mild to moderate MG participated in this study. During the first month, they performed five training sessions per week. For the following 3 months, training frequency was reduced to five sessions per two weeks. Myasthenia score, lung function, and respiratory endurance were determined prior to training, after the first month, and after 4 months. Myasthenia score improved from0.71±0.1to0.56±0.1(P=0.007). Respiratory endurance time increased from6.1±0.8to20.3±3.0min (P<0.001). In conclusion, this RMET maintenance program is feasible and is significantly beneficial for MG patients.

[学科分类] 内科医学