Automated synthesis of radiopharmaceuticals for positron emissiontomography: an apparatus for labelling with [11C] methyl iodide (MIASA)

[摘要] A fully automated apparatus for the routine synthesis andformulation of short-lived11C (t1/2=20min) labelled radiopharmaceuticalsfor positron emission tomography (PET) hasbeen developed. [11C]Carbon dioxide is converted to [11C]methyliodide, which can be used to label a wide variety of substrates bymethylation at C, N, O, or S electron rich centres. The apparatus,MIASA (methyl iodide automated synthesis apparatus), wasdesigned to operate as part of an automated labelling system in ashielded ‘hot’ laboratory. The apparatus was designed without thesize constraints of typical instrumentation used in hot cells, althoughit is compact where necessary. Ample use of indicators and sensors,together with compact design of the reaction flasks for small deadspace and efficient evaporation, led to good reliability andperformance. The design of the hardware and software is describedin this paper, together with a preparation of 3-N-[11C]methylspiperoneas a sterile injectable solution in physiological saline.

[学科分类] 分析化学