Tissue-specific down-regulation of RIPK 2 inMycobacterium leprae-infected nu/nu mice

[摘要] RIPK 2 is adapter molecule in the signal pathway involved in Toll-like receptors. However, there has been no reported association between receptor-interacting serine/threonine kinase 2 (RIPK 2) expression and the infectious diseases involving mycobacterial infection. This study found that its expression was down-regulated in the footpads and skin but was up-regulated in the liver ofMycobacterium leprae-infected nu/nu mice compared with those of theM. lepraenon-infected nu/nu mice. It was observed that the interlukin-12p40 and interferon-γ genes involved in the susceptibility ofM. lepraewere down-regulated in the skin but were up-regulated in the liver. Overall, this suggests that regulation of RIPK 2 expression is tissue-specifically associated withM. lepraeinfection.

[学科分类] 生理学与病理学