A Polymorphism ofORAI1rs7135617, Is Associated with Susceptibility to Rheumatoid Arthritis

[摘要] Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors.ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune diseases. To identify whetherORAI1gene contributes to RA susceptibility, we enrolled 400 patients with RA and 621 healthy individuals for a case-control genetic association study. Five tagging single nucleotides polymorphisms (tSPNs) withinORAI1gene were selected for genotyping. An SNP, rs7135617, showed a significant correlation with the risk of RA. Our results indicated that genetic polymorphism ofORAI1gene is involved in the susceptibility of RA in a Taiwanese population.

[学科分类] 生理学与病理学