Hyaluronic Acid Inhibits Polycation Induced Cellular Responses

[摘要] Positively charged macromolecules cause a variety of pathologicalevents through their electrostatic interaction with anionic sitespresent on the membrane of target cells. In the present study we haveinvestigated the effect of hyaluronic acid, a negatively chargedmolecule, on rat paw oedema induced by poly-L-lysine as well as onhistamine release from rat mast cells and nitric oxide formationfrom rabbit aorta, both induced by this polycation. The resultsindicate that hyaluronic acid is able to suppress thesepoly-L-lysine induced effects with a mechanism which possiblydepends on its negative charges which may balance the effects ofpositively charged polycations.

[学科分类] 生理学与病理学