Changes and Relationship of PAF and TNF in Rats with Myocardial Ischaemia and Reperfusion Injury

[摘要] In this study it is reported that: (1) the levels of bloodplatelet-activating factor and serum tumour necrosis factorsignificantly increased after coronary ligation and reperfusion,compared with sham-ligated controls, in an anaesthetized rat model;(2) compared with vehicle controls, pretreatment with the PAFantagonist BN 50739 (10 mg/kg, i.v.) produced significantdecreases in infarct size (from 29.6 ± 4.0% to 22.4± 2.1%,p<0.05after 3 h ligation, and from28.5 ± 9.5% to 10.5 ± 4.5%,p<0.01after 4 h reperfusion) and the level of serum TNF (from 10.4± 7.7 U/ml to 3.9 ± 4.8 U/ml,p<0.05); and (3) a significan positive correlation was found between thelevel of blood PAF or serum TNF and infarct size. The presentresults indicate that PAF and TNF may be important mediatorsinvolved in myocardial ischaemia and reperfusion injury, and thatPAF antagonists may exert a protective effect on ischaemic orreperfused myocardium by inhibiting the interaction of PAF and TNF.

[学科分类] 生理学与病理学