A comparison of the Antileukaemic Effects of Recombinant HumanTumour Necrosis Factor-α and its Muteins on Leukaemia L1210 and Leukaemia P388 in Mice

[摘要] We investigated the influence of recombinant human tumour necrosisfactor alpha (TNF-α) and its derivatives termed muteins III, V,VI—in which the first 3 to 7 amino acids of native TNF-α have beenreplaced—on the survival time of mice inoculated with leukaemiaL1210 or leukaemia P338. TNF-α prolonged the survival of mice withleukaemia L1210 but did not have any therapeutic activity inleukaemia P388-bearing mice. Muteins-treated mice with leukaemiaP388 lived longer than animals receiving TNF-α, while thoseinoculated with leukaemia L1210 did not show any significantprolongation of life compared with the TNF-α treated group. Theresults presented in this report indicate that the antileukaemicactivity of TNF-α is governed at least in part by the nature of theN-terminal amino acids.

[学科分类] 生理学与病理学